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BIOLOGICAL DIVERSITY
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Group
I Cluster |
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MMSET type I (MMSET) |
Cell Growth/Differentiation |
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GDP-L-fucose:beta-D-galactoside 2-alpha-l-Fucosyltransferase |
Metabolism, carbohydrate |
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Cellular growth-regulating protein |
Cell Growth |
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Gro-beta (melanoma stimulating growth factor) |
Cell Growth |
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Pim-1 |
Signal Transduction, oncogenes |
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Neuoron-specific gamma-2 enolase |
Development/Differentiation |
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Nuclear matrix protein NRP/B (NRPB) |
DNA Transcription/Differentiation |
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Natural killer cell stimulatory factor (IL-12) |
Hematopoiesis, Immune Response |
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Granulocyte-macrophage colony stimulating factor (GM-CSF) |
Hematopoiesis |
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Adipogenesis inhibitory factor (IL-11) |
Hematopoiesis, metabolism |
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Natural resistance-associated macrophage protein |
Immune Response |
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Interleukin 1-beta |
Inflammation |
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Tumor necrosis factor |
Inflammation |
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Group
II Cluster |
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Apoptosis inducing (TRAIL) receptor 2 |
AF016849 | Apoptosis |
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Death receptor 5 (DR5) |
AF012535 | Apoptosis |
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K-ras oncogene protein |
M54968 | Signal Transduction |
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Thioredoxin reductase |
S79851 | Metabolism, Redox |
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Interleukin-10 receptor |
U00672 | Immune Regulation, receptors |
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Tyrosine kinase (ELK1) oncogene |
M25269 | Transcriptional Regulation |
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6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFKFB) |
AF109735 | Metabolism, carbohydrate |
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Inducible 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (IPFK-2) |
AF056320 | Metabolism, carbohydrate |
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MOP1, basic-helix-loop-helix-PAS |
U29165 | Transcriptional Regulation |
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Cytokine-inducible SH2-containing protein (G18) |
AF132297 | Signal Transduction, inhibitors |
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K-Cl cotransporter KCC4 |
AF10536 | Nutrient Transport |
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Dishevelled 1 (DVL1) |
AF006011 | Signal Transduction |
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Guanine nucleotide regulatory factor (LFP40) |
U72206 | Cellular Motility/biogenesis |
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Zinc finger containing protein ZNF157 (ZNF157) |
U28687 | DNA Transcription |
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Tubulin-folding cofactor C |
U61234 | Cellular motility/biogenesis |
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Interferon(LyIFN-alpha-1) |
E00102 | Immune Response, Innate |
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Alpha-interferon Gx-1 |
E00124 | Immune Response, Innate |
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Inteferon-alpha |
V00542 | Immune response, Innate |
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Leukocyte interferon-alpha, clone pIFN105 |
M28585 | Immune Response, Innate |
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Interferon alpha J |
E00052 | Immune Response, Innate |
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Messenger RNA for human leukocyte interferon |
V00542 | Immune Response, Innate |
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Angiotensin/vasopressin receptor AII/AVP |
AF054176 | Signal Transduction, receptors |
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c-fos proto-oncogene |
V01512 | Transcriptional Regulation |
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Group
III Cluster |
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Interferon (IFN-alpha-M1) |
M27318 | Immune Response, Innate |
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B-cell leukemia/lymphoma 2 (bcl-2) proto-oncogene |
M13994 | Apoptosis |
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Condoroitin 6-sulfotransferase |
AB017915 | Metabolism, sulphate |
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Sodium bicarbonate cotransporter 3 (SLC4A7) |
AF047033 | Metabolism, Transport |
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Cyclooxygenase-2 (Cox-2) |
M90100 | Inflammation |
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Neuralized mRNA |
AF029729 | Development, neural |
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Gro (growth regulated) gene |
J03561 | Cellular Growth |
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Epiregulin |
D30783 | Cellular growth |
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A-kinase anchor protein |
U17195 | Signal Transduction |
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CREB-binding protein |
U47741 | Transcriptional Regulation |
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L-type amino acid transporter subunit LAT1 |
AF104032 | Nutrient Transport |
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Zinc-finger DNA-binding motifs (IA-1) |
M93119 | Transcriptional Regulation |
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Interleukin 3 |
M20137 | Haematopoiesis |
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E16 |
M80244 | Signal Transduction, receptors |
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2-oxoglutarate dehydrogenase |
D10523 | Metabolism, energy |
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SIRP-beta1 |
Y10376 | Signal Transduction, inhibitors |
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Putative sulphate transporter (PDS) |
AF030880 | Nutrient Transport |
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Interleukin 2 (IL2) |
U25676 | Immune Response, adaptive |
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Post-synaptic density protein 95 (PSD95) |
U83192 | Neural Regulation |
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Dihydrolipoamide dehydrogenase-binding protein |
AF001437 | Metabolism, energy |
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Type 2 iodothyronine deiodinase |
AF093774 | Metabolism, hormones |
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RGP G-protein 3 |
U27655 | Signal Transduction |
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Alpha endosulfine |
AF067170 | Nutrient Transport, regulation |
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Tumor necrosis factor alpha inducible A20 zinc finger protein |
M59465 | Transcriptional Regulation |
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Vascular endothelial growth factor |
AF022375 | Cellular Growth, angiogenesis |
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Inhibitor of apoptosis protein-1 (MIHC) |
AF070674 | Apoptosis, regulation |
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A28-RGS14p |
U70426 | Signal Transduction |
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TNFR2-TRAF signaling complex protein |
L49432 | Transcriptional Regulation |
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Fibrillin-2 |
U03272 | Cellular Motility/Biogenesis |
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Farnesylated-proteins converting enzyme 1 |
Y13834 | Protein modification |
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D-1 dopamine receptor |
X58987 | Signal Transduction, neural |
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HEB helix-loop-helix protein (HEB) |
M80627 | Transcriptional Regulation |
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IFN-omega 1 |
A12140 | Immune Response, innate |
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Interferon beta |
X04430 | Immune Response, innate |
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Lymphotoxin |
E01275 | Immune Response |
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Musashi/Nrp-1 |
AB012851 | Development, neural |
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Thiamine carrier 1 (TC1) |
AF153330 | Metabolism, nutrient transport |
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Transcription factor (HTF4A) |
M83233 | Transcription |
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Phospholipase C-beta-2 |
M95678 | Signal Transduction |
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Onconeural ventral antigen-1 (Nova-1) |
U04840 | Development/Differentiaion, neural |
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Protein tyrosine kinase mRNA |
M59371 | Signal Transduction |
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Tyrosine kinase receptor p145TRK-B (TRK-B) |
U12140 | Signal Transduction, receptors |
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Protein-tyrosine phosphatase |
U27193 | Signal Transduction, inhibitors |
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Transcriptional regulatory protein p54 |
AF045451 | Transcriptional Regulation |
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cAMP phosphodiesterase PDE7 (PDE7A1 |
L12052 | Signal Transduction |
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Retinoic acid receptor gamma 1 |
M38258 | Transcriptional Regulation, receptors |
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Tissue factor (thromboplastin) |
A19048 | Inflammation |
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c-sis/platelet derived growth factor 2 (PDGF2) |
AF022375 | Cellular growth, oncogenes |
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Endothelial leukocyte adhesion molecule-1 (ELAM-1) |
M30640 | Inflammation |
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Group
IV Cluster |
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175 sequences available with other group at http://rc.kfshrc.edu.sa/ared |
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Group
V Cluster |
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582 sequences available with other group at http://rc.kfshrc.edu.sa/ared |
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The ARE-mRNAs were clustered into five groups containing five, four, three, and two pentameric repeats, while the last group contains only one pentamer within the 13-bp ARE pattern. Functional categories were assigned whenever possible according to NCBI-COG functional annotation (77) (in addition to the categories: inflammation, immune response, Development/Differentiation (using an extensive PubMed literature search. Those ARE-mRNAs, which do not have known biological function in Groups I-III are not shown in the table. Members of the training list (Table 1) are highlighted in bold. |