Transplantation is done for a variety of liver diseases including acute (sudden) liver failure, certain types of liver cancer, and most commonly for cirrhosis of the liver. Cirrhosis of the liver can be caused by viruses such as Hepatitis B and C infection; autoimmune diseases such as primary biliary cirrhosis and primary sclerosing cholangitis; alcohol, and other diseases. Other forms of liver disease that can be successfully treated with liver transplantation include Wilson's disease (excess copper in the liver), hemochromatosis (excess iron in the liver), and various other rare metabolic and genetic disorders.